Title: The Development of Pro-Apoptotic Cancer Therapeutics
VOLUME: 8 ISSUE: 7
Author(s):Noha I. Ziedan, Hachemi Kadri and Andrew D. Westwell
Affiliation:Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3XF, UK.
Keywords:Pro-apoptotic cancer therapy, selective antitumour agents, apoptosis, small molecules, mitochondria-targeting, Xlinked inhibitor of apoptosis (XIAP), B-cell lymphoma 2 (Bcl-2), aerobic glycolysis
Abstract: Resistance to apoptosis is one of the fundamental hallmarks of cancer. Recently, the selective induction of apoptosis in cancer cells has emerged as an exciting possibility for the development of future selective cancer therapy. This review will summarise the development of the major classes of small molecule “pro-apoptotic” antitumour agents.
