Abstract
Resistance to apoptosis is one of the fundamental hallmarks of cancer. Recently, the selective induction of apoptosis in cancer cells has emerged as an exciting possibility for the development of future selective cancer therapy. This review will summarise the development of the major classes of small molecule “pro-apoptotic” antitumour agents.
Keywords: Pro-apoptotic cancer therapy, selective antitumour agents, apoptosis, small molecules, mitochondria-targeting, Xlinked inhibitor of apoptosis (XIAP), B-cell lymphoma 2 (Bcl-2), aerobic glycolysis
Mini-Reviews in Medicinal Chemistry
Title: The Development of Pro-Apoptotic Cancer Therapeutics
Volume: 8 Issue: 7
Author(s): Noha I. Ziedan, Hachemi Kadri and Andrew D. Westwell
Affiliation:
Keywords: Pro-apoptotic cancer therapy, selective antitumour agents, apoptosis, small molecules, mitochondria-targeting, Xlinked inhibitor of apoptosis (XIAP), B-cell lymphoma 2 (Bcl-2), aerobic glycolysis
Abstract: Resistance to apoptosis is one of the fundamental hallmarks of cancer. Recently, the selective induction of apoptosis in cancer cells has emerged as an exciting possibility for the development of future selective cancer therapy. This review will summarise the development of the major classes of small molecule “pro-apoptotic” antitumour agents.
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Cite this article as:
Ziedan I. Noha, Kadri Hachemi and Westwell D. Andrew, The Development of Pro-Apoptotic Cancer Therapeutics, Mini-Reviews in Medicinal Chemistry 2008; 8 (7) . https://dx.doi.org/10.2174/138955708784567430
DOI https://dx.doi.org/10.2174/138955708784567430 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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