Suppression of Cancer Invasiveness by Dietary Compounds

Author(s): Daniel Sliva.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 7 , 2008

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Abstract:

Tumor invasion and cancer metastasis are interrelated processes involving cell growth, cell adhesion, cell migration and proteolytic degradation of tissue barriers, which are mediated by aberrant intracellular signaling in cancer cells. Natural (green tea polyphenols, soy isoflavones) or dietary compounds (mushroom G. lucidum) markedly decreased AP-1 and NF-κB signaling and suppressed invasiveness of cancer cells. This review will summarize alternative approaches for the inhibition of invasive behavior of cancer cells by dietary compounds, which can be considered in adjuvant or combination therapy for the prevention and treatment of cancer metastasis.

Keywords: Cancer invasion, metastasis, green tea, isoflavones, triterpenes, signaling

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Article Details

VOLUME: 8
ISSUE: 7
Year: 2008
Page: [677 - 688]
Pages: 12
DOI: 10.2174/138955708784567412
Price: $58

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