Computational Analysis Suggests Beta-Defensins Are Processed to Mature Peptides By Signal Peptidase
Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of β-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of β- defensin expression compared with other AMP genes.
Keywords: Antimicrobial peptide, innate immunity, host defense, signal sequence
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