Computational Analysis Suggests Beta-Defensins Are Processed to Mature Peptides By Signal Peptidase
Nicholas Beckloff and Gill Diamond
Pages 536-540 (5)
Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of β-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of β- defensin expression compared with other AMP genes.
Antimicrobial peptide, innate immunity, host defense, signal sequence
Department of Oral Biology, UMDNJ-New Jersey Dental School, 185 South Orange Ave., Newark, NJ 07103, USA.