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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 15
ISSUE: 5
DOI: 10.2174/092986608784567618      Price:  $58









Computational Analysis Suggests Beta-Defensins Are Processed to Mature Peptides By Signal Peptidase

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Author(s): Nicholas Beckloff and Gill Diamond
Pages 536-540 (5)
Abstract:
Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of β-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of β- defensin expression compared with other AMP genes.
Keywords:
Antimicrobial peptide, innate immunity, host defense, signal sequence
Affiliation:
Department of Oral Biology, UMDNJ-New Jersey Dental School, 185 South Orange Ave., Newark, NJ 07103, USA.