Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Computational Analysis Suggests Beta-Defensins Are Processed to Mature Peptides By Signal Peptidase

Author(s): Nicholas Beckloff, Gill Diamond.

Abstract:

Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of β-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of β- defensin expression compared with other AMP genes.

Keywords: Antimicrobial peptide, innate immunity, host defense, signal sequence

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Article Details

VOLUME: 15
ISSUE: 5
Page: [536 - 540]
Pages: 5
DOI: 10.2174/092986608784567618
Price: $58