Computational Analyses of TBC Protein Family in Eukaryotes
Xinjiao Gao, Changjiang Jin, Yu Xue and Xuebiao Yao
Affiliation: Laboratory of Cellular Dynamics, Hefei National Laboratory for Physical Science at Microscale; and the University of Science and Technology of China, Hefei, Anhui 230027, China.
Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.
Keywords: TBC domain, phylogenetic tree, USP6, polarized exocytosis, cell cycle, cytokinesis
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