Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Computational Analyses of TBC Protein Family in Eukaryotes

Author(s): Xinjiao Gao, Changjiang Jin, Yu Xue and Xuebiao Yao

Affiliation: Laboratory of Cellular Dynamics, Hefei National Laboratory for Physical Science at Microscale; and the University of Science and Technology of China, Hefei, Anhui 230027, China.

Keywords: TBC domain, phylogenetic tree, USP6, polarized exocytosis, cell cycle, cytokinesis

Abstract:

Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.

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Article Details

VOLUME: 15
ISSUE: 5
Page: [505 - 509]
Pages: 5
DOI: 10.2174/092986608784567483