Natural Protective Amyloids

Author(s): Vassiliki A. Iconomidou, Stavros J. Hamodrakas.

Journal Name: Current Protein & Peptide Science

Volume 9 , Issue 3 , 2008

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Abstract:

Amyloidoses are a group of diseases including neurodegenerative diseases like Alzheimers disease and also type II diabetes, spongiform encephalopathies and many others, believed to be caused by protein aggregation and subsequent amyloid fibril formation. However, occasionally, living organisms exploit amyloid fibril formation, a property inherent into amino acid sequences, and perform specific physiological functions from amyloids, in differing biological contexts. Some of these functional amyloids are natural protective amyloids. Here, we review recent evidence on silkmoth chorion protein synthetic peptide-analogues that documents the function of silkmoth chorion, the major component of the eggshell, a structure with extraordinary physiological and mechanical properties, as a natural protective amyloid. Also, we briefly discuss the reported function of other natural, protective amyloids like fish chorion, the protein Pmel17 which forms amyloid fibrils that act as templates and accelerate the covalent polymerization of reactive small molecules into melanin, the hydrophobins and the antifreeze protein from winter flounder. Molecular self-assembly is becoming an increasingly popular route to new supramolecular structures and molecular materials and the inspiration for such structures is commonly derived from self-assembling systems in biology. Therefore, a careful examination of these studies may set the basis for the exploration of new routes for the formation of novel biocompatible polymeric structures with exceptional physico-chemical properties, for potentially new biomedical and industrial applications.

Keywords: Amyloids, natural protective amyloids, silkmoth chorion protein peptide analogues, amyloid fibrillogenesis, liquid crystals, β-pleated sheet, fish chorion, Pmel17, hydrophobins, antifreeze protein

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2008
Page: [291 - 309]
Pages: 19
DOI: 10.2174/138920308784534041
Price: $58

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