Role of the Region 23-28 in Aβ Fibril Formation: Insights from Simulations of the Monomers and Dimers of Alzheimers Peptides Aβ40 and Aβ42

Author(s): Adrien Melquiond, Xiao Dong, Normand Mousseau, Philippe Derreumaux.

Journal Name: Current Alzheimer Research

Volume 5 , Issue 3 , 2008

Abstract:

Self-assembly of the 40/42 amino acid Aβ peptide is a key player in Alzheimers disease. Aβ40 is the most prevalent species, while Aβ42 is the most toxic. It has been suggested that the amino acids 21-30 could nucleate the folding of Aβ monomer and a bent in this region could be the rate-limiting step in Aβ fibril formation. In this study, we review our current understanding of the computer-predicted conformations of amino acids 23-28 in the monomer of Aβ(21-30) and the monomers Aβ40 and Aβ42. On the basis of new simulations on dimers of full-length Aβ, we propose that the ratelimiting step involves the formation of a multimeric β-sheet spanning the central hydrophobic core (residues 17-21).

Keywords: Protein aggregation, simulations, Amyloid-beta, Alzheimer, coarse-grained model, structures, thermodynamics, monomer and dimer

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2008
Page: [244 - 250]
Pages: 7
DOI: 10.2174/156720508784533330
Price: $58

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