Statins-Mediated Inhibition of Rho GTPases as a Potential Tool in Anti-Tumor Therapy

Author(s): Chiara Riganti , Elisabetta Aldieri , Sophie Doublier , Amalia Bosia , Dario Ghigo .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 6 , 2008

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Abstract:

Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.

Keywords: Rho GTPases, cancer, isoprenylation, statins, chemotherapy

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2008
Page: [609 - 618]
Pages: 10
DOI: 10.2174/138955708784534436
Price: $58

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