Abstract
Saponins are plant glycosides with favorable anti-tumorigenic properties. Several saponins inhibit tumor cell growth by cell cycle arrest and apoptosis with IC50 values of up to 0.2 μM. We discuss diverse groups of saponins (dioscins, saikosaponins, julibrosides, soy saponins, ginseng saponins and avicins) investigated in relation to tumor therapy and focus on cellular and systemic mechanisms of tumor cell growth inhibition both in vitro and in vivo. The review also describes saponins in combination with conventional tumor treatment strategies, which result in improved therapeutic success. Some combinations of saponins and anti-tumorigenic drugs induce synergistic effects with potentiated growth inhibition.
Keywords: Saponin, cancer, tumor therapy, cytotoxicity, triterpenoid, steroid, glycoside
Mini-Reviews in Medicinal Chemistry
Title: Saponins in Tumor Therapy
Volume: 8 Issue: 6
Author(s): Christopher Bachran, Silke Bachran, Mark Sutherland, Diana Bachran and Hendrik Fuchs
Affiliation:
Keywords: Saponin, cancer, tumor therapy, cytotoxicity, triterpenoid, steroid, glycoside
Abstract: Saponins are plant glycosides with favorable anti-tumorigenic properties. Several saponins inhibit tumor cell growth by cell cycle arrest and apoptosis with IC50 values of up to 0.2 μM. We discuss diverse groups of saponins (dioscins, saikosaponins, julibrosides, soy saponins, ginseng saponins and avicins) investigated in relation to tumor therapy and focus on cellular and systemic mechanisms of tumor cell growth inhibition both in vitro and in vivo. The review also describes saponins in combination with conventional tumor treatment strategies, which result in improved therapeutic success. Some combinations of saponins and anti-tumorigenic drugs induce synergistic effects with potentiated growth inhibition.
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Cite this article as:
Bachran Christopher, Bachran Silke, Sutherland Mark, Bachran Diana and Fuchs Hendrik, Saponins in Tumor Therapy, Mini-Reviews in Medicinal Chemistry 2008; 8 (6) . https://dx.doi.org/10.2174/138955708784534445
DOI https://dx.doi.org/10.2174/138955708784534445 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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