Abstract
Tea is a popular beverage with a number of putative beneficial health effects. A recent large epidemiological study in Japan demonstrates that increased tea consumption is associated with decreased cardiovascular mortality (but not cancer mortality) in a dose-dependent manner. The polyphenol epigallocatechin-3-gallate (EGCG) is the most abundant tea catechin. Beneficial effects of EGCG therapy have been reported in a number of human and animal studies. Emerging evidence suggests that EGCG may improve endothelial function, hypertension, coronary heart disease, obesity, insulin resistance, as well as glucose and lipid metabolism. Studies in cultured cells and animal models suggest molecular mechanisms for EGCG to activate specific cellular signaling pathways that may play major roles in prevention and amelioration of cardiovascular and metabolic diseases. In this review, the beneficial health effects of tea and molecular mechanisms of EGCG related to cardiovascular and metabolic diseases will be discussed.
Keywords: epigallocatechin, Hypertension, cardiovascular disease, epicatechin, mediated brachial artery dilation, Dyslipidemia
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: Mechanisms Underlying Beneficial Health Effects of Tea Catechins to Improve Insulin Resistance and Endothelial Dysfunction
Volume: 8 Issue: 2
Author(s): Jeong-A. Kim
Affiliation:
Keywords: epigallocatechin, Hypertension, cardiovascular disease, epicatechin, mediated brachial artery dilation, Dyslipidemia
Abstract: Tea is a popular beverage with a number of putative beneficial health effects. A recent large epidemiological study in Japan demonstrates that increased tea consumption is associated with decreased cardiovascular mortality (but not cancer mortality) in a dose-dependent manner. The polyphenol epigallocatechin-3-gallate (EGCG) is the most abundant tea catechin. Beneficial effects of EGCG therapy have been reported in a number of human and animal studies. Emerging evidence suggests that EGCG may improve endothelial function, hypertension, coronary heart disease, obesity, insulin resistance, as well as glucose and lipid metabolism. Studies in cultured cells and animal models suggest molecular mechanisms for EGCG to activate specific cellular signaling pathways that may play major roles in prevention and amelioration of cardiovascular and metabolic diseases. In this review, the beneficial health effects of tea and molecular mechanisms of EGCG related to cardiovascular and metabolic diseases will be discussed.
Export Options
About this article
Cite this article as:
Kim Jeong-A., Mechanisms Underlying Beneficial Health Effects of Tea Catechins to Improve Insulin Resistance and Endothelial Dysfunction, Endocrine, Metabolic & Immune Disorders - Drug Targets 2008; 8 (2) . https://dx.doi.org/10.2174/187153008784534349
DOI https://dx.doi.org/10.2174/187153008784534349 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Folate Nutrigenetics: A Convergence of Dietary Folate Metabolism, Folic Acid Supplementation, and Folate Antagonist Pharmacogenetics
Drug Metabolism Letters Outcome of Heart Failure with Preserved Ejection Fraction: A Multicentre Spanish Registry
Current Cardiology Reviews Safety Limits of Antidepressant Use Plus Combinations: Focus on Cardiovascular Function
Current Drug Metabolism Drainage of Cerebral Abscesses Prior to Valve Replacement in Stable Patients with Acute Left-Sided Infective Endocarditis
CNS & Neurological Disorders - Drug Targets In Vivo, Cardiac-Specific Knockdown of a Target Protein, Malic Enzyme- 1, in Rat via Adenoviral Delivery of DNA for Non-Native miRNA
Current Gene Therapy Resistant Hypertension in the Elderly-Second Line Treatments: Aldosterone Antagonists, Central Alpha-Agonist Agents, Alpha-Adrenergic Receptor Blockers, Direct Vasodilators, and Exogenous Nitric Oxide Donors
Cardiovascular & Hematological Agents in Medicinal Chemistry HDL - Cholesterol: The New Target for Treatment
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Sobetirome: A Selective Thyromimetic for the Treatment of Dyslipidemia
Recent Patents on Cardiovascular Drug Discovery Cardiovascular Effects of Omega-3 Free Fatty Acids.
Current Vascular Pharmacology Opportunities for Pharmacotherapy at the Intersection of Metabolic Syndrome and Hemostasis
Current Pharmaceutical Biotechnology The Evidence Base for Revascularisation of Chronic Total Occlusions
Current Cardiology Reviews High Blood Pressure and the Risk of Stroke
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Pathogenic Subpopulation of Th17 Cells in Obesity
Current Pharmaceutical Design Oxidative Stress and Antioxidant Potential of One Hundred Medicinal Plants
Current Topics in Medicinal Chemistry Stem Cell Implantation for Myocardial Disorders
Current Drug Delivery Diet and Metabolic Syndrome
Endocrine, Metabolic & Immune Disorders - Drug Targets The Therapeutic Potential of Hepatocyte Growth Factor for Myocardial Infarction and Heart Failure
Current Pharmaceutical Design The Double Roles of the Prostaglandin E<sub>2</sub> EP2 Receptor in Intracerebral Hemorrhage
Current Drug Targets Effects of Physical Exercise on Inflammatory Markers of Atherosclerosis
Current Pharmaceutical Design Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury
Mini-Reviews in Medicinal Chemistry