Recent Developments in the Discovery of Selective Glucocorticoid Receptor Modulators (SGRMs)

Author(s): Andrew R. Hudson, Steven L. Roach, Robert I. Higuchi.

Journal Name: Current Topics in Medicinal Chemistry

Volume 8 , Issue 9 , 2008

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Steroidal glucocorticoids are widely prescribed for the treatment of a variety of inflammatory and autoimmune diseases. Although they are effective, the side-effects associated with chronic glucocorticoid treatment, such as osteoporosis and hyperglycemia, can severely limit their long-term use. Hence, there is a need to develop new effective anti-inflammatory agents for systemic use which are dissociated from their unwanted side effects.

Keywords: SGRM, glucocorticoid, nonsteroidal, modulator, transactivation, transrepression, dissociated, inflammation, multiple myeloma

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Article Details

Year: 2008
Page: [750 - 765]
Pages: 16
DOI: 10.2174/156802608784535048
Price: $65

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