Tetrahydroisoquinoline-Related Modulators of Multidrug Resistance in Cancer
Hui Bin Zhang,
Wen Long Huang,
Yun Man Li.
A series of novel tetrahydroisoquinoline derivatives (7a-b and 8a-j) were synthesized by using N – cyanoguanyl as a spacer, and their multidrug resistance reversal activities against K562/A02 cell line in vitro were evaluated by MTT method. It was found that 7a and 8b showed more potent multidrug resistance reversal activities than verapamil.
Keywords: Tetrahydroisoquinoline, N, –, cyanoguanyl, Synthesis, MDR, Modulator, P-glycoprotein
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