Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Tetrahydroisoquinoline-Related Modulators of Multidrug Resistance in Cancer

Author(s): Yu Li, Hui Bin Zhang, Wen Long Huang, Xia Zhen, Yun Man Li.

Abstract:

A series of novel tetrahydroisoquinoline derivatives (7a-b and 8a-j) were synthesized by using N – cyanoguanyl as a spacer, and their multidrug resistance reversal activities against K562/A02 cell line in vitro were evaluated by MTT method. It was found that 7a and 8b showed more potent multidrug resistance reversal activities than verapamil.

Keywords: Tetrahydroisoquinoline, N, –, cyanoguanyl, Synthesis, MDR, Modulator, P-glycoprotein

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [303 - 306]
Pages: 4
DOI: 10.2174/157018008784619834
Price: $58