Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Modulation by Dopaminergic System of Morphine Withdrawal: In Vitro Evidences

Author(s): A. Capasso.

Abstract:

The effects exerted by cocaine, amphetamine and phencyclidine on the acute opiate withdrawal induced by morphine were investigated in vitro. The results of our experiments indicate that cocaine, amphetamine and phencyclidine are able to influence opiate withdrawal in vitro thus confirming an important functional interaction between the dopaminergic system and opioid withdrawal.

Keywords: Dependence, Dopamine, Morphine, Cocaine, Amphetamine, Phencyclidine

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [297 - 301]
Pages: 5
DOI: 10.2174/157018008784619906
Price: $58