Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Antimalarial Activity of 2,4-Diaminopyrimidines

Author(s): J. Morgan, R. Haritakul, P. A. Keller.

Abstract:

A series of 2,4- and 4,6-diaminopyrimidines were prepared and evaluated for their in vitro antimalarial activity. Of the 12 compounds tested 7 showed reasonable activity with 1 having a sub-micromolar IC50.

Keywords: Antimalarial, Diaminopyrimidine, Structure-activity relationship

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [277 - 280]
Pages: 4
DOI: 10.2174/157018008784619843
Price: $58