Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Anticancer Activity of Phthalimido and Naphthalimido Substituted Dihydropyrimidone Conjugates

Author(s): Ahmed Kamal, S. F. Adil, Jaki R. Tamboli, B. Siddardha, U. S.N. Murthy.

Abstract:

A series of phthalimido-dihydropyrimidones (19a-l) and naphthalimido-dihydropyrimidones (23a-l) have been synthesized and some representative compounds have been evaluated for their in vitro anticancer activity. Compounds 19d, 19f and 19j are selectively active against leukemia while showing moderate activity against broad spectrum of cancer cell lines. The compounds (19a-l) and (23a-l) also have been evaluated for their antibacterial and antifungal activities.

Keywords: Biginelli reaction, One-pot synthesis, Dihydropyrimidinones, Phthalimide, Naphthalimide, Anticancer

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [261 - 270]
Pages: 10
DOI: 10.2174/157018008784619933
Price: $58