Abstract
A series of Schiff bases 1-20 was synthesised by the condensation of isatin with primary aromatic amines. All the synthesized compounds 1-20 were randomly screened for their in vitro anti-leishmanial potential. Compounds 2, 5, 7, 10, 13 and 16 also showed good anti-leishmanial activities having IC50 value 4.77 ± 0.1, 6.85 ± 0.21, 1.84 ± 0.2, 2.44 ± 0.03, 4.70 ± 0.04 and 8.58 ± 0.04 μg/mL, respectively. Remaining compounds with IC50 values grater than 10.00 μg/mL were considered to be inactive. Their activity was compared with standard drugs, amphotericin B (IC50 = 0.12 ± 0.41 μg/mL) and pentamidine (IC50 = 2.56 ± 0.1 μg/mL). The structures of all the synthesised compounds were deduced by spectroscopic analysis.
Letters in Drug Design & Discovery
Title: Schiff Bases of Istain: Potential Anti-Leishmanial Agents
Volume: 5 Issue: 4
Author(s): Khalid Mohammed Khan, Uzma Rasool Mughal, Samreen, Shahnaz Perveen and Muhammad Iqbal Choudhary
Affiliation:
Abstract: A series of Schiff bases 1-20 was synthesised by the condensation of isatin with primary aromatic amines. All the synthesized compounds 1-20 were randomly screened for their in vitro anti-leishmanial potential. Compounds 2, 5, 7, 10, 13 and 16 also showed good anti-leishmanial activities having IC50 value 4.77 ± 0.1, 6.85 ± 0.21, 1.84 ± 0.2, 2.44 ± 0.03, 4.70 ± 0.04 and 8.58 ± 0.04 μg/mL, respectively. Remaining compounds with IC50 values grater than 10.00 μg/mL were considered to be inactive. Their activity was compared with standard drugs, amphotericin B (IC50 = 0.12 ± 0.41 μg/mL) and pentamidine (IC50 = 2.56 ± 0.1 μg/mL). The structures of all the synthesised compounds were deduced by spectroscopic analysis.
Export Options
About this article
Cite this article as:
Khan Mohammed Khalid, Mughal Rasool Uzma, Samreen , Perveen Shahnaz and Choudhary Iqbal Muhammad, Schiff Bases of Istain: Potential Anti-Leishmanial Agents, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619915
DOI https://dx.doi.org/10.2174/157018008784619915 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Gene Polymorphism of Angiotensin II Type 1 and Type 2 Receptors
Current Pharmaceutical Design Scope and Limitations of The Co-Drug Approach to Topical Drug Delivery
Current Pharmaceutical Design Cardiac ATP-Sensitive Potassium Channels: A Potential Target for an Anti-Ischaemic Pharmacological Strategy
Cardiovascular & Hematological Agents in Medicinal Chemistry The Management and Outcomes of Pharmacological Treatments for Tinnitus
Current Neuropharmacology Protective Effects of Anesthetics on the Spinal Cord
Current Pharmaceutical Design Type 2 Diabetes Mellitus and the Elderly: An Update on Drugs Used to Treat Glycaemia
Current Vascular Pharmacology Editorial [Hot Topic: Autoimmunity (Executive Editors: D. Stahl and W. Sibrowski)]
Current Pharmaceutical Design The Impact of Substance P on the Pathogenesis of Insulin Resistance Leading to Gestational Diabetes
Current Pharmaceutical Biotechnology Cardiotoxicity of Molecularly Targeted Agents
Current Cardiology Reviews Mechanisms of Action and Chemical-Biological Interactions Between Ozone and Body Compartments: A Critical Appraisal of the Different Administration Routes
Current Drug Therapy Augmentation Strategies for Clozapine-Resistant Patients with Schizophrenia
Current Pharmaceutical Design Update in the Management of Diastolic Heart Failure
Current Vascular Pharmacology Evaluation of In Vivo Efficacy of Aqueous Extract of Aerial Parts of Cynodon dactylon in Rats with Simultaneous Type 2 Diabetes and Hypertension
Current Bioactive Compounds The Use of Propolis in Micro/Nanostructured Pharmaceutical Formulations
Recent Patents on Drug Delivery & Formulation Mechanism-Based Treatment in Chronic Neuropathic Pain: The Role of Antidepressants
Current Pharmaceutical Design Medical Treatment of Hirsutism in Women
Current Medicinal Chemistry Cardiovascular Effects Mediated by Imidazoline Drugs: An Update
Cardiovascular & Hematological Disorders-Drug Targets Gymnema sylvestre R. Br., an Indian Medicinal Herb: Traditional Uses, Chemical Composition, and Biological Activity
Current Pharmaceutical Biotechnology The Cardiorenal Syndrome: Pathophysiologic Crosstalk, Outcomes, and Treatment Targets
Cardiovascular & Hematological Disorders-Drug Targets Localisation of Endothelin-1 and its Receptors in Vascular Tissue as Seen at the Electron Microscopic Level
Current Vascular Pharmacology