Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

Schiff Bases of Istain: Potential Anti-Leishmanial Agents

Author(s): Khalid Mohammed Khan, Uzma Rasool Mughal, Samreen, Shahnaz Perveen, Muhammad Iqbal Choudhary.

Abstract:

A series of Schiff bases 1-20 was synthesised by the condensation of isatin with primary aromatic amines. All the synthesized compounds 1-20 were randomly screened for their in vitro anti-leishmanial potential. Compounds 2, 5, 7, 10, 13 and 16 also showed good anti-leishmanial activities having IC50 value 4.77 ± 0.1, 6.85 ± 0.21, 1.84 ± 0.2, 2.44 ± 0.03, 4.70 ± 0.04 and 8.58 ± 0.04 μg/mL, respectively. Remaining compounds with IC50 values grater than 10.00 μg/mL were considered to be inactive. Their activity was compared with standard drugs, amphotericin B (IC50 = 0.12 ± 0.41 μg/mL) and pentamidine (IC50 = 2.56 ± 0.1 μg/mL). The structures of all the synthesised compounds were deduced by spectroscopic analysis.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [243 - 249]
Pages: 7
DOI: 10.2174/157018008784619915
Price: $58