Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Design and Synthesis of Carbohydrate Derivatives for Antagonistic Activity at Muscarinic Receptor

Author(s): David R. da Rocha, Vitor F. Ferreira, Lucia Garcez-do-Carmo, Wilson C. Santos.

Abstract:

Effects of carbohydrate derivatives, synthesized exploring D-Glucose as starting material were studied in rat jejunum and tested in the muscarinic neurotransmission. The compounds shifted rightward and reduced maximum effect of curves for ACh. In KCl curves, they produced relaxing effects. Based on these experiments we suggest that these compounds act as non-competitive antagonists.

Keywords: Carbohydrates, Cholinergic neurotransmission, Muscarinic receptor, Atropine

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [236 - 242]
Pages: 7
DOI: 10.2174/157018008784619870
Price: $58