An Integrated Rule-Set for Protein Localization in Plasmodium falciparum
Sri Jyothsna Yeleswarapu,
Proteins localize to many intracellular and extracellular organelles in the malarial parasite Plasmodium falciparum. Although organellar localization in the parasite has been studied in detail, there is a need for a comprehensive ruleset that captures the different paths and mechanisms used by proteins for localization. This review is an attempt to build such a rule-set through a combination of rules gleaned from literature reports. A prototype localization prediction tool has also been implemented by incorporating certain sequence/composition rules from the rule-set.
Keywords: Plasmodium falciparum, protein localization, integrated rule-set, Targetpf
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