Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University
Melbourne
Australia

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An Integrated Rule-Set for Protein Localization in Plasmodium falciparum

Author(s): Aditya Rao, Sri Jyothsna Yeleswarapu, Rajgopal Srinivasan, Gopalakrishnan Bulusu.

Abstract:

Proteins localize to many intracellular and extracellular organelles in the malarial parasite Plasmodium falciparum. Although organellar localization in the parasite has been studied in detail, there is a need for a comprehensive ruleset that captures the different paths and mechanisms used by proteins for localization. This review is an attempt to build such a rule-set through a combination of rules gleaned from literature reports. A prototype localization prediction tool has also been implemented by incorporating certain sequence/composition rules from the rule-set.

Keywords: Plasmodium falciparum, protein localization, integrated rule-set, Targetpf

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2008
Page: [66 - 73]
Pages: 8
DOI: 10.2174/157489308784340685
Price: $58