The Effect of Soybean Oil on Glycaemic Control in Goto-Kakizaki Rats,an Animal Model of Type 2 Diabetes

Author(s): Cristina M. Sena, Teresa Proenca, Elsa Nunes, Maria S. Santos, Raquel M. Seica.

Journal Name: Medicinal Chemistry

Volume 4 , Issue 3 , 2008

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Several studies in humans and laboratory animals with type 2 diabetes indicate that antioxidant supplements lessen the impact of oxidative damage caused by dysregulation of glucose metabolism. The present study was undertaken to examine the effect of soybean oil on glycaemic control and lipid metabolism in Goto-kakizaki (GK) rats, a model of type 2 diabetes. Rats were divided into three groups, a control group of non-diabetic (Wistar) rats, a group of diabetic GK rats and a group of GK rats treated with soybean oil. Plasma samples from the different groups were analysed for total α- tocopherol, coenzyme Q and glucose levels. Glycated haemoglobin was also compared between the different groups. Fasting and non-fasting blood glucose levels were significantly decreased in soybean oil group compared with GK group. There was also a 14 % reduction in the levels of HbA1c in SO-treated GK when compared with the diabetic control group. Diabetes induced a decrease in coenzyme Q plasma levels that prevailed after treatment with soybean oil. Moreover, the plasma α-tocopherol levels were higher after treatment with soybean oil. Conclusions: Our observations suggest that soybean oil treatment may be beneficial in type 2 diabetes. Since soybean oil has very high amounts of coenzyme Q and other antioxidants one possible mechanism of action could be as an antioxidant.

Keywords: Type 2 diabetes, Goto-Kakizaki rats, soybean oil, antioxidants, CoQ10

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Article Details

Year: 2008
Page: [293 - 297]
Pages: 5
DOI: 10.2174/157340608784325115
Price: $58

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