Abstract
Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results suggest that they can be potential candidates for a drug of choice for influenza chemotherapy.
Keywords: Influenza virus, chemotherapy, antioxidant, apoptosis, cytokines, superoxide, macrophages
Mini-Reviews in Medicinal Chemistry
Title: Future Target Molecules for Influenza Treatment
Volume: 8 Issue: 5
Author(s): N. Uchide and H. Toyoda
Affiliation:
Keywords: Influenza virus, chemotherapy, antioxidant, apoptosis, cytokines, superoxide, macrophages
Abstract: Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results suggest that they can be potential candidates for a drug of choice for influenza chemotherapy.
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Cite this article as:
Uchide N. and Toyoda H., Future Target Molecules for Influenza Treatment, Mini-Reviews in Medicinal Chemistry 2008; 8 (5) . https://dx.doi.org/10.2174/138955708784223530
DOI https://dx.doi.org/10.2174/138955708784223530 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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