Mini-Reviews in Medicinal Chemistry

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Future Target Molecules for Influenza Treatment

Author(s): N. Uchide, H. Toyoda.

Abstract:

Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results suggest that they can be potential candidates for a drug of choice for influenza chemotherapy.

Keywords: Influenza virus, chemotherapy, antioxidant, apoptosis, cytokines, superoxide, macrophages

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Article Details

VOLUME: 8
ISSUE: 5
Page: [491 - 495]
Pages: 5
DOI: 10.2174/138955708784223530
Price: $58