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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Future Target Molecules for Influenza Treatment

Author(s): N. Uchide and H. Toyoda

Volume 8, Issue 5, 2008

Page: [491 - 495] Pages: 5

DOI: 10.2174/138955708784223530

Price: $65

Abstract

Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results suggest that they can be potential candidates for a drug of choice for influenza chemotherapy.

Keywords: Influenza virus, chemotherapy, antioxidant, apoptosis, cytokines, superoxide, macrophages


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