Abstract
Natural polyphenols are a wide class of secondary plant metabolites and represent an abundant antioxidant component of human diet. An important, but often neglected group of natural polyphenols, are tannins. This review offers a general description of chemistry of both hydrolysable and condensed tannins (proanthocyanidins), the mechanisms of their antioxidation action, like free radical scavenging activity, chelation of transition metals, inhibition of prooxidative enzymes and lipid peroxidation. The mechanisms of action of antibacterial, antiviral, anticarcinogenic, cardiovascular system preventing, and antiinflammatory effects as well as the absorption, metabolic fate and positive in vivo effects of tannins are enclosed.
Keywords: Tannins, antioxidant, diseases, proanthocyanidins, free radicals, biological activity, phlorotannins
Mini-Reviews in Medicinal Chemistry
Title: Condensed and Hydrolysable Tannins as Antioxidants Influencing the Health
Volume: 8 Issue: 5
Author(s): Vit Koleckar, Katerina Kubikova, Zuzana Rehakova, Kamil Kuca, Daniel Jun, Ludek Jahodar and Lubomir Opletal
Affiliation:
Keywords: Tannins, antioxidant, diseases, proanthocyanidins, free radicals, biological activity, phlorotannins
Abstract: Natural polyphenols are a wide class of secondary plant metabolites and represent an abundant antioxidant component of human diet. An important, but often neglected group of natural polyphenols, are tannins. This review offers a general description of chemistry of both hydrolysable and condensed tannins (proanthocyanidins), the mechanisms of their antioxidation action, like free radical scavenging activity, chelation of transition metals, inhibition of prooxidative enzymes and lipid peroxidation. The mechanisms of action of antibacterial, antiviral, anticarcinogenic, cardiovascular system preventing, and antiinflammatory effects as well as the absorption, metabolic fate and positive in vivo effects of tannins are enclosed.
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Cite this article as:
Koleckar Vit, Kubikova Katerina, Rehakova Zuzana, Kuca Kamil, Jun Daniel, Jahodar Ludek and Opletal Lubomir, Condensed and Hydrolysable Tannins as Antioxidants Influencing the Health, Mini-Reviews in Medicinal Chemistry 2008; 8 (5) . https://dx.doi.org/10.2174/138955708784223486
DOI https://dx.doi.org/10.2174/138955708784223486 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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