Asymmetric Synthesis of α-Unsubstituted β-Hydroxy Acids

Author(s): Jan Spengler, Fernando Albericio.

Journal Name: Current Organic Synthesis

Volume 5 , Issue 2 , 2008

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Abstract:

α-Unsubstituted β-hydroxy acids (3-hydroxycarboxylic acids) are constituents of various natural products with pharmacological and other technical properties of interest. They are also important intermediates in organic synthesis. This article reviews various possible routes for asymmetric synthesis of enantiopure or enantiomerically enriched α-unsubstituted β-hydroxy acids.

Keywords: 3-hydroxycarboxylic acids, asymmetric aldol reactions, Reformatsky reactions, asymmetric reduction, Arndt-Eistert homologation, β-lactones, cyclic sulfites, cyclic sulfates, reductive cleavage

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2008
Page: [151 - 161]
Pages: 11
DOI: 10.2174/157017908784221558
Price: $58

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