Abstract
In this review we focus on epidermal stem cells in the normal regeneration of the skin as well as in wounded and psoriatic skin. Furthermore, we discuss current data supporting the idea of cancer stem cells in the pathogenesis of skin carcinoma and malignant melanoma. Epidermal stem cells present in the basal layer of the interfollicular epidermis and in the bulge region of the hair follicle play a critical role for normal tissue maintenance. In wound healing, multipotent epidermal stem cells contribute to re-epithelization. It is possible that defects in growth control of either epidermal stem cells or transit amplifying cells constitute a primary pathogenetic factor in the epidermal hyperproliferation seen in psoriasis. In cutaneous malignancies mounting evidence supports a stem cell origin in skin carcinoma and malignant melanoma and a possible existence of cancer stem cells.
Keywords: Epidermal stem cells, wound healing, psoriasis, skin carcinoma, malignant melanoma
Current Stem Cell Research & Therapy
Title: Epidermal Stem Cells - Role in Normal, Wounded and Pathological Psoriatic and Cancer Skin
Volume: 3 Issue: 2
Author(s): Maria Kamstrup, Annesofie Faurschou, Robert Gniadecki and Hans Christian Wulf
Affiliation:
Keywords: Epidermal stem cells, wound healing, psoriasis, skin carcinoma, malignant melanoma
Abstract: In this review we focus on epidermal stem cells in the normal regeneration of the skin as well as in wounded and psoriatic skin. Furthermore, we discuss current data supporting the idea of cancer stem cells in the pathogenesis of skin carcinoma and malignant melanoma. Epidermal stem cells present in the basal layer of the interfollicular epidermis and in the bulge region of the hair follicle play a critical role for normal tissue maintenance. In wound healing, multipotent epidermal stem cells contribute to re-epithelization. It is possible that defects in growth control of either epidermal stem cells or transit amplifying cells constitute a primary pathogenetic factor in the epidermal hyperproliferation seen in psoriasis. In cutaneous malignancies mounting evidence supports a stem cell origin in skin carcinoma and malignant melanoma and a possible existence of cancer stem cells.
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Cite this article as:
Kamstrup Maria, Faurschou Annesofie, Gniadecki Robert and Wulf Christian Hans, Epidermal Stem Cells - Role in Normal, Wounded and Pathological Psoriatic and Cancer Skin, Current Stem Cell Research & Therapy 2008; 3 (2) . https://dx.doi.org/10.2174/157488808784223087
DOI https://dx.doi.org/10.2174/157488808784223087 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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