Abstract
Rapid estrogen actions are triggered after estrogens are bound to a variety of proteins in organelles other than the nucleus. Those include classic estrogen receptors ERα and ERβ, novel membrane proteins that behave as estrogen receptors such as GPR30, ion channels, and other ligand receptors. In pancreatic α and β-cells, estrogens binding to a non-classical membrane estrogen receptors at physiological concentrations regulate ion channels and [Ca2+]i signals, provoking important physiological responses. In β-cells, 17β- estradiol regulates KATP channel activity and glucose-induced [Ca2+]i oscillations, eliciting changes in insulin release and the activation of Ca2+-dependent transcription factors. In α-cells, 17β-estradiol abolishes low glucose-induced [Ca2+]i oscillations.
Infectious Disorders - Drug Targets
Title: Rapid Regulation of Pancreatic α- and β- Cell Signalling Systems by Estrogens
Volume: 8 Issue: 1
Author(s): Cristina Ripoll, Ana B. Ropero, Paloma Alonso-Magdalena, Ivan Quesada, Esther Fuentes and Angel Nadal
Affiliation:
Abstract: Rapid estrogen actions are triggered after estrogens are bound to a variety of proteins in organelles other than the nucleus. Those include classic estrogen receptors ERα and ERβ, novel membrane proteins that behave as estrogen receptors such as GPR30, ion channels, and other ligand receptors. In pancreatic α and β-cells, estrogens binding to a non-classical membrane estrogen receptors at physiological concentrations regulate ion channels and [Ca2+]i signals, provoking important physiological responses. In β-cells, 17β- estradiol regulates KATP channel activity and glucose-induced [Ca2+]i oscillations, eliciting changes in insulin release and the activation of Ca2+-dependent transcription factors. In α-cells, 17β-estradiol abolishes low glucose-induced [Ca2+]i oscillations.
Export Options
About this article
Cite this article as:
Ripoll Cristina, Ropero B. Ana, Alonso-Magdalena Paloma, Quesada Ivan, Fuentes Esther and Nadal Angel, Rapid Regulation of Pancreatic α- and β- Cell Signalling Systems by Estrogens, Infectious Disorders - Drug Targets 2008; 8 (1) . https://dx.doi.org/10.2174/187152608784139668
DOI https://dx.doi.org/10.2174/187152608784139668 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Carnosine and Kidney Diseases: What We Currently Know?
Current Medicinal Chemistry Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases
Current Medicinal Chemistry The Pattern of Carbohydrate Intake among University Students from Eastern Indonesia Tends to be Diverse
Current Nutrition & Food Science Angiotensin II Type 1 and Type 2 Receptor-induced Cell Signaling
Current Pharmaceutical Design Endothelin-1: The Yin and Yang on Vascular Function
Current Medicinal Chemistry Biological Effect of Glycosyl-Oxadiazolinethione and Glycosyl-sulfanyloxadiazole Derivatives through their in vitro Inhibition of Glycosidases from Bacteria and Normal or Diabetic Rats
Letters in Drug Design & Discovery Physicochemical Parameters of Non-Viral Vectors that Govern Transfection Efficiency
Current Gene Therapy Editorial: Liraglutide and Cardiometabolic Effects: More than Just Another Antiobesity Drug?
Current Vascular Pharmacology Editorial: News in Cardiovascular Surgery Treatment: Is there Anything to do Before and After it?
Current Vascular Pharmacology Radiation-Induced Extracranial Carotid Stenosis
Vascular Disease Prevention (Discontinued) Innate Immunity and Microbes: Conversations with the Gut Leading to Intestinal Tissue Repair and Fibrosis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Opioid Receptor Ligands Derived from Food Proteins
Current Pharmaceutical Design The Development of High-throughput Identification and Heterologous Expression of Valuable Peptides/Proteins
Current Proteomics Involvement of Advanced Glycation End-products (AGEs) in Alzheimers Disease
Current Alzheimer Research Adrenoceptor Polymorphisms in Hypertension and Diabetes with Obesity- Update in 2013
Current Hypertension Reviews Getting Rid of Intracellular Aβ - Loss of Cellular Degradation Leads to Transfer Between Connected Neurons
Current Pharmaceutical Design Interleukin-15 in Gene Therapy of Cancer
Current Gene Therapy The Clinical Significance of PPAR Gamma Agonism
Current Molecular Medicine Identification and Characterization of Peptides and Proteins in Doping Control Analysis
Current Proteomics Soluble CD40L and its Role in Essential Hypertension: Diagnostic and Therapeutic Implications
Cardiovascular & Hematological Disorders-Drug Targets