Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents

Author(s): Marcus Vinicius Nora de Souza, Marcelle de Lima Ferreira, Thais Cristina Mendonca Nogueira, Raoni Schroeder Borges Goncalves, Monica Amado Peralta, Maria Cristina Silva Lourenco, Felipe Rodrigues Vicente.


The present article describes a series of eleven N-(alkyl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μgmL. . The compounds 3g and 3k exhibited the respective activities of 25 and 50 μg/mL being a new class of compounds against tuberculosis.

Keywords: Tuberculosis, Multidrug-resistance, Thiophene, Thiopheneacetamides, Antimycobacterial activity, Alamar blue assay

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Year: 2008
Page: [221 - 224]
Pages: 4
DOI: 10.2174/157018008784083965
Price: $58