Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents

Author(s): Marcus Vinicius Nora de Souza, Marcelle de Lima Ferreira, Thais Cristina Mendonca Nogueira, Raoni Schroeder Borges Goncalves, Monica Amado Peralta, Maria Cristina Silva Lourenco, Felipe Rodrigues Vicente.

Abstract:

The present article describes a series of eleven N-(alkyl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μgmL. . The compounds 3g and 3k exhibited the respective activities of 25 and 50 μg/mL being a new class of compounds against tuberculosis.

Keywords: Tuberculosis, Multidrug-resistance, Thiophene, Thiopheneacetamides, Antimycobacterial activity, Alamar blue assay

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2008
Page: [221 - 224]
Pages: 4
DOI: 10.2174/157018008784083965
Price: $58