Inherent Gene Expression Variabilities and the Need for Personalized Drug Dosage
Simulations of the effects of DNA polymorphisms, transcriptional noise, and epigenetic differences within and among populations suggest highly divergent responses to drug dosage, resulting in considerable risk of adverse effects. These findings highlight the need for personalized calibration of drug dosage.
Keywords: Personalized medicine, Dosage selection, Genetic polymorphism, Gene expression variability, Gene regulatory networks, Systems biology
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