Abstract
Simulations of the effects of DNA polymorphisms, transcriptional noise, and epigenetic differences within and among populations suggest highly divergent responses to drug dosage, resulting in considerable risk of adverse effects. These findings highlight the need for personalized calibration of drug dosage.
Keywords: Personalized medicine, Dosage selection, Genetic polymorphism, Gene expression variability, Gene regulatory networks, Systems biology
Letters in Drug Design & Discovery
Title: Inherent Gene Expression Variabilities and the Need for Personalized Drug Dosage
Volume: 5 Issue: 3
Author(s): Hamid Bolouri
Affiliation:
Keywords: Personalized medicine, Dosage selection, Genetic polymorphism, Gene expression variability, Gene regulatory networks, Systems biology
Abstract: Simulations of the effects of DNA polymorphisms, transcriptional noise, and epigenetic differences within and among populations suggest highly divergent responses to drug dosage, resulting in considerable risk of adverse effects. These findings highlight the need for personalized calibration of drug dosage.
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Cite this article as:
Bolouri Hamid, Inherent Gene Expression Variabilities and the Need for Personalized Drug Dosage, Letters in Drug Design & Discovery 2008; 5 (3) . https://dx.doi.org/10.2174/157018008784084036
DOI https://dx.doi.org/10.2174/157018008784084036 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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