Estrogen Receptor: Structural Differences and Potential Implications on Selectivity Examined by the GRID/CPCA Approach

Author(s): I. R.A. de Menezes, A. Leitao, C. A. Montanari.

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 3 , 2008

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Selective Estrogen Receptor Modulators (SERMs) have been developed, but the selectivity towards the subtypes (ERα or ERβ) is not well understood. Based on three-dimensional structural properties of ligand binding domains, a model that takes into account this aspect was developed via molecular interaction fields and consensus principal component analysis (GRID/CPCA).

Keywords: ER subtypes, consensus PCA, selective estrogen receptor modulators, SERM, ligand binding domain, key interactions

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Article Details

Year: 2008
Page: [182 - 192]
Pages: 11
DOI: 10.2174/157018008784083947
Price: $65

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