Estrogen Receptor: Structural Differences and Potential Implications on Selectivity Examined by the GRID/CPCA Approach

Title: Estrogen Receptor: Structural Differences and Potential Implications on Selectivity Examined by the GRID/CPCA Approach

Volume: 5 Issue: 3

Author(s): I. R.A. de Menezes, A. Leitao and C. A. Montanari

Affiliation:

Keywords: ER subtypes, consensus PCA, selective estrogen receptor modulators, SERM, ligand binding domain, key interactions

Abstract: Selective Estrogen Receptor Modulators (SERMs) have been developed, but the selectivity towards the subtypes (ERα or ERβ) is not well understood. Based on three-dimensional structural properties of ligand binding domains, a model that takes into account this aspect was developed via molecular interaction fields and consensus principal component analysis (GRID/CPCA).

Cite this article as:

de Menezes R.A. I., Leitao A. and Montanari A. C., Estrogen Receptor: Structural Differences and Potential Implications on Selectivity Examined by the GRID/CPCA Approach, Letters in Drug Design & Discovery 2008; 5 (3) . https://dx.doi.org/10.2174/157018008784083947