Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Antimalarial Activity of Novel Hydroxyethylamines,Potential Aspartyl Protease Inhibitors

Author(s): Wilson Cunico, Maria de Lourdes G. Ferreira, Thais G. Ferreira, Carmen Penido, Maria G.M.O. Henriques, Luisa G. Krettli, Fernando P. Varotti, Antoniana U. Krettli.

Abstract:

Parasite resistance to antimalarial drugs is a serious threat to human health, and novel agents that act on essential enzymes for parasite metabolism, such as proteases, are attractive targets for drug development. In this work, the antimalarial activity of hydroxyethylamine derivatives have been evaluated in vitro against Plasmodium falciparum W2 clone chloroquine resistant. These results show that the some compounds have moderated activity against malaria parasite.

Keywords: Hydroxyethylamine, Antimalarial, Protease inhibitors

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2008
Page: [178 - 181]
Pages: 4
DOI: 10.2174/157018008784083938
Price: $58