New 3-Aminosteroid Derivatives as a New Family of Topical Antibacterial Agents Active against Methicillin-Resistant Staphylococcus aureus (MRSA)
Jean Michel Brunel.
A series of new 3-aminosteroid derivatives was evaluated for their in vitro antimicrobial properties against human pathogens such as Gram positive bacteria. They are active against multi-resistant cocci, especially Methicillin- Resistant Staphylococcus aureus (MRSA) at average concentrations of 2.5-5.0 μg/mL and are particularly suitable for topical antibacterial use.
Keywords: Squalamine, Aminosteroid derivatives, Antibacterial agents, Resistance, MRSA
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