A Simple and Efficient One-Pot Synthesis of Spirooxindoles in Water Under Microwave Irradiation Conditions

Author(s): Song-Lei Zhu , Shun-Jun Ji , Kai Zhao , Yong Zhang .

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 4 , 2008

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Abstract:

A simple and efficient method for the synthesis of spirooxindoles derivatives by one-pot reactions of isatins, activated methylene reagents and activated carbonyl compounds in water under microwave irradiation was reported. This protocol has the advantages of short reaction time, high yields, easy work-up procedure and environmentally benign characters.

Keywords: Spirooxindoles, three-component synthesis, microwave irradiation, aqueous media

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [319 - 323]
Pages: 5
DOI: 10.2174/157017808784049489
Price: $58