Chemoselective and Efficient Method for Deprotection of THP and Silyl Ethers with H2O2/ Mn(III) Schiff-Base Complex

Author(s): Mahmood Tajbakhsh, Rahman Hosseinzadeh, Hamid Golchoubian, Raheleh Razavian.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 4 , 2008

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Abstract:

Mn(III) Schiff-base complex as a catalyst with H2O2 was applied for oxidative deprotection of THP ethers to the corresponding carbonyl compounds and conversion of silyl ethers into the parent alcohols under mild conditions. Chemoselective cleavage of trimethylsilyl ethers in the presence of t-butyldimethylsilyl ethers and cleavage of trimethylsilyl ethers in the presence of tetrahydropyranyl ethers were also achieved with this system.

Keywords: THP ether, silyl ether, deprotection, Mn(III) Schiff-base complex, hydrogen peroxide

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [308 - 312]
Pages: 5
DOI: 10.2174/157017808784049506
Price: $58

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