Abstract
2-Carbethoxy-6-acetylpyridine and 2,6-diacetylpyridine were transformed in good yields from the reaction of 2,6-dicarbethoxypyridine and EtOAc in the presence of sodium along with/without an equivalent of ethanol to sodium in toluene. The β-keto esters, the intermediates in the transformation of β-keto carboxylate into acetyl group, were isolated for understanding the plausible mechanism.
Keywords: 2-Carbethoxy-6-acetylpyridine, 2,6-diacetylpyridine, 2,6-dicarbethoxypyridine, Claisen Ester Condensation, anti-Claisen reaction
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