A Novel Four Component One-Pot Access to 4,6-diaryl-2-Pyridinone and 4-aryl-5,6,7,8-tetrahydro-2-quinolinones

Author(s): Chao-Guo Yan, Xi-Mei Cai, Qi-Fang Wang, Jing Sun.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 4 , 2008

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Abstract:

An efficient one-pot procedure was developed for the synthesis of 4,6-diaryl-2-pyridinones and 4-aryl-8- arylidene-5,6,7,8-tetrahydro-2- quinolinones based on cyclocondensation reactions of N-ethoxycarbonylmethylpyridinium chloride or N-carbamoylmethyl pyridinium chloride with aromatic aldehydes and substituted acetophenones or cyclohexanone. The multi-component reaction is performed by microwave irradiation with the reaction substances in the system of NH4OAc/HOAc.

Keywords: Pyridine, pyridone, quinolinone, microwave irradiation, multi-component reaction, cyclocondensation

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [282 - 285]
Pages: 4
DOI: 10.2174/157017808784049425
Price: $58

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