Current Alzheimer Research

Debomoy K. Lahiri  
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202


η-Secretase: Reduction of Amyloid Precursor Protein η-Site Cleavage in Alzheimers Disease

Author(s): Fuyuki Kametani

Affiliation: Tokyo Institute of Psychiatry,Tokyo Metropolitan Organization for Medical Research, 2-1-8 Kamikitazawa,Setagaya-ku, Tokyo 156-8585, Japan.


The accumulation and deposition of fibrillar Aβ is thought the primary cause of Alzheimers disease (AD). Aβ is generated by sequential proteolytic processing involving β- and γ-secretase on Amyloid β protein precursor (APP). Recently, γ-secretase was shown to cleave near the cytoplasmic membrane boundary of APP, called η-site cleavage, as well as in the middle of the membrane domain, called γ-site cleavage. Recent findings indicate that γ- and η-site cleavage are regulated independently. In this review, the reduction of η-site cleavage in AD and the importance of η-site cleavage are discussed.

Keywords: Alzheimer's disease, APP, presenilin, γ-secretase, Aβ, AICD, η-secretase

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Article Details

Page: [165 - 171]
Pages: 7
DOI: 10.2174/156720508783954776
Price: $58