Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Propofol and Systemic Inflammatory Response in Abdominal Aortic Surgery

Author(s): Jose M. Rodriguez-Lopez, Francisco S. Lozano.

Abstract:

Abdominal aortic surgery is relatively common associated with considerable postoperative morbidity and mortality. The aortic cross-clamping for the implantation of a vascular prosthetic graft induces a systemic inflammatory response (SIR) because of an ischemia-reperfusion (IR) injury. In our experimental models we have reported that propofol anesthesia, compared with sevoflurane, after IR modulates SIR and this effect might result in renal protection.

Keywords: Propofol, Systemic inflammatory response, Aortic surgery, Aortic cross-clamping

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2008
Page: [148 - 151]
Pages: 4
DOI: 10.2174/157018008783928490
Price: $58