Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Antitubercular Evaluation of N-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide Derivatives

Author(s): Marcelle de L. Ferreira, Laura N. de F. Cardoso, Raoni S.B. Goncalves, Emerson T. da Silva, Maria Cristina S. Lourenco, Felipe R. Vicente, Marcus V.N. de Souza.


The present article describes a series of eighteen N-[(E)-(hydroxy, methoxy and ethoxy substitutedphenyl) methylidene]isonicotinohydrazide derivatives, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μg/ml. Compounds 2a, 2d-f, and 2h exhibited a significant activity (0.31-1.25 μg/ml) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good start point to find new lead compounds in the fight against multi-drug resistant tuberculosis.

Keywords: Tuberculosis, Multidrug-resistance, Isoniazid, Isonicotinohydrazides, Antimycobacterial activity, Alamar Blue assay

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Article Details

Year: 2008
Page: [137 - 140]
Pages: 4
DOI: 10.2174/157018008783928472
Price: $58