Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Antitubercular Evaluation of N-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide Derivatives

Author(s): Marcelle de L. Ferreira, Laura N. de F. Cardoso, Raoni S.B. Goncalves, Emerson T. da Silva, Maria Cristina S. Lourenco, Felipe R. Vicente, Marcus V.N. de Souza.

Abstract:

The present article describes a series of eighteen N-[(E)-(hydroxy, methoxy and ethoxy substitutedphenyl) methylidene]isonicotinohydrazide derivatives, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μg/ml. Compounds 2a, 2d-f, and 2h exhibited a significant activity (0.31-1.25 μg/ml) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good start point to find new lead compounds in the fight against multi-drug resistant tuberculosis.

Keywords: Tuberculosis, Multidrug-resistance, Isoniazid, Isonicotinohydrazides, Antimycobacterial activity, Alamar Blue assay

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2008
Page: [137 - 140]
Pages: 4
DOI: 10.2174/157018008783928472
Price: $58