Synthesis and Biological Activity of New Tricyclic Purine Derivatives Obtained by Intramolecular N-7 Alkylation
Arturene Maria Lino Carmo,
Fernanda Gambogi Braga,
Marcio Luiz De Paula,
Ana Paula Ferreira,
Henrique Couto Teixeira,
Adilson David da Silva,
Elaine Soares Coimbra.
Intramolecular N-7 alkylation of 6-substituted purines gave rise to a new series of tricyclic purine derivatives. The new compounds were evaluated for their cytotoxicity, their antileishmania activity together with their capacity to modulate NO production in macrophages. As a result compound 1 exhibited a modest activity against KB cells. On the other hand 4a was active against Leishmania and it diminished NO production of BCG-induced J774A.1 cells.
Keywords: Purine analogues, Antileishmania, Anticancer, NO production
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