Synthesis and Biological Activity of New Tricyclic Purine Derivatives Obtained by Intramolecular N-7 Alkylation

Author(s): Arturene Maria Lino Carmo, Fernanda Gambogi Braga, Marcio Luiz De Paula, Ana Paula Ferreira, Henrique Couto Teixeira, Adilson David da Silva, Elaine Soares Coimbra.

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 2 , 2008

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Abstract:

Intramolecular N-7 alkylation of 6-substituted purines gave rise to a new series of tricyclic purine derivatives. The new compounds were evaluated for their cytotoxicity, their antileishmania activity together with their capacity to modulate NO production in macrophages. As a result compound 1 exhibited a modest activity against KB cells. On the other hand 4a was active against Leishmania and it diminished NO production of BCG-induced J774A.1 cells.

Keywords: Purine analogues, Antileishmania, Anticancer, NO production

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2008
Page: [122 - 126]
Pages: 5
DOI: 10.2174/157018008783928535
Price: $58

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