Phenylpyazoleanilides as a Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 1: A New Class of Orally Available Immunomodulators

Author(s): Hiroyuki Ushio , Seigo Ishibuchi , Kunitomo Adachi , Kouichi Oshita , Kenji Chiba .

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 2 , 2008

Become EABM
Become Reviewer

Abstract:

In research for a new immunomodulator, we discoverd a novel hydroxypiperidine derivative 9h which was a potent inhibitor of IL-15induced T cell activation. Further modification of 9h gave a potent and orally active agent 10 which was effective in a mouse CIA model.

Keywords: Phenylpyrazoleanilide, IL-15, Prodrug, CIA

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 5
ISSUE: 2
Year: 2008
Page: [111 - 115]
Pages: 5
DOI: 10.2174/157018008783928427

Article Metrics

PDF: 29