Four known small molecule uracil-DNA glycosylase (UNG) inhibitors were synthesized and tested against human melanoma cells, IgR3 and MM200. They were found to be effective against cell proliferation at micromolar concentrations and to operate through a nonapoptotic mechanism. Thus, small molecules that target UNG may be useful as potential chemotherapeutic agents against human melanoma.
Keywords: Uracil-DNA glycosylase, Small molecule inhibitors, Chemo-preventive agents, Melanoma, IgR3, MM200, Anticancer drugs
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