Current Topics in Medicinal Chemistry

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA


Biologically Active Chitosan Systems for Tissue Engineering and Regenerative Medicine

Author(s): Cato T. Laurencin, Tao Jiang, Sangamesh G. Kumbar and Lakshmi S. Nair

Affiliation: Department of Orthopaedic Surgery, University of Virginia, 400 Ray C. Hunt Drive, Suite 330,Charlottesville, VA 22908, USA.


Biodegradable polymeric scaffolds are widely used as a temporary extracellular matrix in tissue engineering and regenerative medicine. By physical adsorption of biomolecules on scaffold surface, physical entrapment of biomolecules in polymer microspheres or hydrogels, and chemical immobilization of oligopeptides or proteins on biomaterials, biologically active biomaterials and scaffolds can be derived. These bioactive systems show great potential in tissue engineering in rendering bioactivity and/or specificity to scaffolds. This review highlights some of the biologically active chitosan systems for tissue engineering application and the associated strategies to develop such bioactive chitosan systems.

Keywords: Chitosan, bioactive, biomolecules, scaffolds, surface modification, tissue engineering, regenerative medicine

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Article Details

Page: [354 - 364]
Pages: 11
DOI: 10.2174/156802608783790974
Price: $58