HPLC as a Tool in Medicinal Chemistry for the Monitoring of Tricyclic Antidepressants in Biofluids

Author(s): V. F. Samanidou, M. K. Nika, I. N. Papadoyannis.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 3 , 2008

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Abstract:

HPLC is discussed as an essential tool in medicinal chemistry for the monitoring of tricyclic antidepressants in biofluids, providing clinicians with efficient fast and reliable methods to define individual optimum therapeutic concentrations in treatment of depressions. Additional information on mechanism of action, structure activity relationship and metabolism is provided.

Keywords: HPLC, tricyclic antidepressants, monitoring, medicinal chemistry, biological fluids

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2008
Page: [256 - 275]
Pages: 20
DOI: 10.2174/138955708783744038
Price: $58

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