An Expedient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and -Thiones Catalyzed by ZIRCONIA Nanopowder. An Improved Protocol for the Biginelli Cyclocondensation Compounds in ‘Dry Media’

Title: An Expedient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and -Thiones Catalyzed by ZIRCONIA Nanopowder. An Improved Protocol for the Biginelli Cyclocondensation Compounds in ‘Dry Media’

Volume: 5 Issue: 2

Author(s): Mannathusamy Gopalakrishnan, Purusothaman Sureshkumar, Jeyaraman Thanusu, Vijayakumar Kanagarajan and Muthuvel R. Ezhilarasi

Affiliation:

Keywords: Cyclocondensation multicomponent reaction, biginelli compounds, 3,4-dihydropyrimidin-2(1H)-ones and, –, thiones, ZrO2 nanopowder, environmentally benign, dry media

Abstract: A general and practical Green Chemistry route to the Biginelli cyclocondensation multicomponent reaction had been carried out by the three-component coupling of β-ketoesters, various structurally diverse aldehydes including heterocyclic aldehydes and urea/thiourea in the presence of Zirconia (ZrO2) nanopowder catalyst in dry media under microwave irradiation and a comparative study was also done under thermal conditions giving 3,4-dihydropyrimidin-2(1H)-ones and -thiones (DHPMs) in excellent yields. Besides, it was highlighted that ZrO2 nanopowder can be reused up to six times after simple washing with ethyl acetate, thus exposing the process economical and environmentally benign.

Cite this article as:

Gopalakrishnan Mannathusamy, Sureshkumar Purusothaman, Thanusu Jeyaraman, Kanagarajan Vijayakumar and Ezhilarasi R. Muthuvel, An Expedient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and -Thiones Catalyzed by ZIRCONIA Nanopowder. An Improved Protocol for the Biginelli Cyclocondensation Compounds in ‘Dry Media’, Letters in Organic Chemistry 2008; 5 (2) . https://dx.doi.org/10.2174/157017808783743911