Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines

Author(s): Laurent Brard, Rakesh K. Singh, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Russell Hopson, Nicholi Vorsa.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 2 , 2008

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Abstract:

The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.

Keywords: Thiazolines, eschenmoser, cytotoxicity, neuroblastoma, ovarian cancer

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2008
Page: [103 - 109]
Pages: 7
DOI: 10.2174/157017808783743966
Price: $58