Abstract
The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.
Keywords: Thiazolines, eschenmoser, cytotoxicity, neuroblastoma, ovarian cancer
Letters in Organic Chemistry
Title: Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines
Volume: 5 Issue: 2
Author(s): Laurent Brard, Rakesh K. Singh, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Russell Hopson and Nicholi Vorsa
Affiliation:
Keywords: Thiazolines, eschenmoser, cytotoxicity, neuroblastoma, ovarian cancer
Abstract: The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.
Export Options
About this article
Cite this article as:
Brard Laurent, Singh K. Rakesh, Lange S. Thilo, Kim K. Kyu, Singh P. Ajay, Hopson Russell and Vorsa Nicholi, Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines, Letters in Organic Chemistry 2008; 5 (2) . https://dx.doi.org/10.2174/157017808783743966
DOI https://dx.doi.org/10.2174/157017808783743966 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Glaucoma Pathogenesis and Neurotrophins: Focus on the Molecular and Genetic Basis for Therapeutic Prospects
Current Neuropharmacology Mechanisms of Prion Protein Aggregation
Protein & Peptide Letters Clostridial Neurotoxins: Mode of Substrate Recognition and Novel Therapy Development
Current Protein & Peptide Science Elucidation of Abnormal Extracellular Regulated Kinase (ERK) Signaling and Associations with Syndromic and Non-syndromic Autism
Current Drug Targets Overview of PCTK3/CDK18: A Cyclin-Dependent Kinase Involved in Specific Functions in Post-Mitotic Cells
Current Medicinal Chemistry Beneficial Effect of Peptides from Microalgae on Anticancer
Current Protein & Peptide Science An Overview of the α4β1 Integrin and the Potential Therapeutic Role of its Antagonists
Current Medicinal Chemistry Radiolabeled Nanoparticles for Cancer Diagnosis and Therapy
Anti-Cancer Agents in Medicinal Chemistry Biochemical, Molecular and Epigenetic Mechanisms of Valproic Acid Neuroprotection
Current Molecular Pharmacology Roles of Natural Compounds from Medicinal Plants in Cancer Treatment: Structure and Mode of Action at Molecular Level
Medicinal Chemistry Mitochondrial Respiration in the Platelets of Patients with Alzheimer’s Disease
Current Alzheimer Research Integrative Neurochemistry and Neurobiology of Social Recognition and Behavior Analyzed with Respect to CD38-Dependent Brain Oxytocin Secretion
Current Topics in Medicinal Chemistry Antibody-Based Targeted Interventions for the Diagnosis and Treatment of Skin Cancers
Anti-Cancer Agents in Medicinal Chemistry An Update on Drug Interactions with the Herbal Medicine Ginkgo biloba
Current Drug Metabolism Improving the Targeting of Tubulin-Binding Agents: Lessons from Drug Resistance Studies
Current Pharmaceutical Design Tumour Re-Differentiation Effect of Retinoic Acid: A Novel Therapeutic Approach for Advanced Thyroid Cancer
Current Pharmaceutical Design Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections
Current Topics in Medicinal Chemistry Drug Targets from Genetics: Alpha-Synuclein
CNS & Neurological Disorders - Drug Targets Involvement of Cytosolic Phospholipase A2, Calcium Independent Phospholipase A2 and Plasmalogen Selective Phospholipase A2 in Neurodegenerative and Neuropsychiatric Conditions
Current Medicinal Chemistry Integrins as Novel Drug Targets for Overcoming Innate Drug Resistance
Current Cancer Drug Targets