13C and 15N isotope labeled precursors and 6-amino-2,3-dimethylpyrimido[4,5-e][1,2,4]
triazine-8-one were synthesized for the mechanistic study of dihydropteridine reductase (DHPR).
Structures of precursors and the inhibitors were confirmed by UV/Vis, 13C NMR, and ESI-MS
Keywords: 13C and 15N isotope labeling, dihydropteridine reductase inhibitor, pyrimido[4, 5-e][1, 2, 4]
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