T-Cell Dysregulation in Systemic Lupus Erythematosus: Pathophysiology and Opportunities for Biomarker Development

Author(s): Frances C. Hall, Christine Bryson, Robert Busch.

Journal Name: Current Rheumatology Reviews

Volume 4 , Issue 1 , 2008

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T cells in SLE patients are dysfunctional as a result of altered signalling inputs and altered signal processing. They contribute to pathogenesis through expansion of autoreactive T cells, aberrant B-cell help and direct T cell-mediated tissue damage. Tissue inflammation and damage, in turn, produce nuclear autoantigens and perpetuate antigen presentation to T cells. Improvements in T cell-targeted therapy will require biomarkers of T-cell dysfunction that predict clinical response. Criteria for defining such biomarkers in SLE are discussed here. Phenotypes associated with T-cell activation, specific effector functions, and/or altered proliferative and homeostatic dynamics are promising candidates.

Keywords: Biomarker, T-cell activation, T-cell signalling, systemic lupus erythematosus, autoimmunity, immunodeficiency, proliferation, lymphopenia, effector function

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Article Details

Year: 2008
Page: [23 - 33]
Pages: 11
DOI: 10.2174/157339708783497892

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PDF: 16