Abstract
Nucleophilic substitution reactions involving propargylic alcohols are important because the alkynyl group can be subsequently transformed into a variety of functional groups. This review summarizes recent direct substitution reactions of hydroxyl groups in propargylic alcohols, reactions that are highly desirable due to atom efficiency and environmental concerns.
Keywords: Ruthenium Catalyzed Substitution, propargylamines, aromatic propargylation, alkoxides, regioselectivity
Current Organic Synthesis
Title: Direct Propargylic Substitution of Hydroxyl Group in Propargylic Alcohols
Volume: 5 Issue: 1
Author(s): George W. Kabalka and Min-Liang Yao
Affiliation:
Keywords: Ruthenium Catalyzed Substitution, propargylamines, aromatic propargylation, alkoxides, regioselectivity
Abstract: Nucleophilic substitution reactions involving propargylic alcohols are important because the alkynyl group can be subsequently transformed into a variety of functional groups. This review summarizes recent direct substitution reactions of hydroxyl groups in propargylic alcohols, reactions that are highly desirable due to atom efficiency and environmental concerns.
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Cite this article as:
Kabalka W. George and Yao Min-Liang, Direct Propargylic Substitution of Hydroxyl Group in Propargylic Alcohols, Current Organic Synthesis 2008; 5 (1) . https://dx.doi.org/10.2174/157017908783497536
DOI https://dx.doi.org/10.2174/157017908783497536 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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