Direct Propargylic Substitution of Hydroxyl Group in Propargylic Alcohols

Author(s): George W. Kabalka, Min-Liang Yao.

Journal Name: Current Organic Synthesis

Volume 5 , Issue 1 , 2008

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Nucleophilic substitution reactions involving propargylic alcohols are important because the alkynyl group can be subsequently transformed into a variety of functional groups. This review summarizes recent direct substitution reactions of hydroxyl groups in propargylic alcohols, reactions that are highly desirable due to atom efficiency and environmental concerns.

Keywords: Ruthenium Catalyzed Substitution, propargylamines, aromatic propargylation, alkoxides, regioselectivity

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Article Details

Year: 2008
Page: [28 - 32]
Pages: 5
DOI: 10.2174/157017908783497536

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