Abstract
Nucleophilic substitution reactions involving propargylic alcohols are important because the alkynyl group can be subsequently transformed into a variety of functional groups. This review summarizes recent direct substitution reactions of hydroxyl groups in propargylic alcohols, reactions that are highly desirable due to atom efficiency and environmental concerns.
Keywords: Ruthenium Catalyzed Substitution, propargylamines, aromatic propargylation, alkoxides, regioselectivity
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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