Recent Patents on CNS Drug Discovery (Discontinued)

Vincenzo Di Marzo
Istituto di Chimica Biomolecolare (I.C.B.)
Consiglio Nazionale delle Ricerche (C.N.R.)
Via Campi Flegrei 34
Pozzuoli, Napoli 80078


Zolpidem Therapy for Movement Disorders

Author(s): Kazuo Abe.


Zolpidem is a selective agonist of the benzodiazepine subtype receptor BZ1. The highest density of this receptor is in the output structures of the basal ganglia. The basal ganglia are pathologically involved in many movements disorders. Thus, zolpidem has accumulated attention for a possible drug to treat neurological signs and symptoms in Parkinsonian diseases. In this mini-review, I reviewed effects of zolpidem as movement disorders including Parkinsons disease, progressive supranuclear palsy, dystonia and so on. In addition, I reviewed a possible mechanism of zolpidem for movement disorders.

Keywords: Zolpidem, movement disorders, gamma-aminobutyric acid (GABA), Parkinson's disease, progressive supranuclear palsy (PSP)

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Article Details

Year: 2008
Page: [55 - 60]
Pages: 6
DOI: 10.2174/157488908783421519